| CONVENER: Prof Sita Naik | ||
| Time | Topic | Learning Objectives |
| 09:00 AM | OPENING Remarks: Prof Sita Naik | |
| 09:05 AM - 09:45 AM | Nuts and Bolts of
Innate immune system BASIC Overview of Innate Immune receptors. Clinical Innate immune aberrations in AIRDs and applications in therapeutics |
Brief Overview of Innate Immunity:
focussing on TLRs. How does it
sense danger and react? Is it
really a perfect creation? Innate immune aberrations in Immunodeficiency/ viral infections and AIRDs Applications in therapeutics - brief overview of TLR antagonists |
| 09:45 AM - 10:25 AM | Interferonopathies: Beyond the Viral Fad BASIC Physiology of interferons and measuring their impact in disease Clinical Monogenic and polygenic interferonopathies and therapeutic options |
Introduction to IFN, its sensors,
signalling pathways, and
Interferon Stimulated genes.
Understanding the interferon
score. Mechanism of major heritable interferonopathies, overview of interferon aberrations in AIRDs (SLE, IIM) and its therapeutic potential. |
| 10:25 AM - 11:05 AM | Complimenting the complements BASIC Biology of complements and its applied aspects CLINICAL Complements in Therapeutic development for AIRDs |
Regulation of complements as relevant to AIRDs
Relevant concepts learnt from pathogenesis of Hereditary angioneurotic edema, HUS and PNH
Development of therapeutics involving complements in autoimmune diseases focusing on Eculizumab and Avocapan (using C5a role in AAV). |
| Tea Break 11:05 AM - 11:30 AM | ||
| 11:30 AM - 12:00 PM | Inflammasome- the balancing act (far and beyond) | Inflammasome: Journey from physiologic role to disease states Therapeutic potential in Immune mediated and Non-immune diseases. RCTs - targeting inflammasome components. |
| 12:00 PM - 12:30 PM | Immune memory-How to train your dragon ? | Innate and adaptive immune memory and its aberrations in AIRDs Mechanism of Vaccine memory. Can it be harnessed for treatment of AIRDs? |
| 12:30 PM - 01:00 PM | Symphony of Cytokine Signalling: Practical Concepts | Overview of cytokine signalling pathways. Learn how different cytokine signalling pathways crosstalk to fine-tune immune responses and maintain homeostasis and what happens when it gets dysregulated How is this knowledge applied in therapeutic strategies of autoimmune diseases? |
| Lunch 01:00 PM - 1:45 PM | ||
| 01:45 PM - 02:15 PM |
Targeting B cells from surface to Core | Brief overview of B cell biology Understanding the B cell targeted therapies. Whether it is to be CD19/20 or 22, or BAFF/APRIL/ or combination/ sequential use? |
| 02:15 PM - 02:45 PM | T cells biology and application in therapy of autoimmune diseases | Quick run thru basics and brief review of Immuno-therapeutics including CAR T cells/ reg T cell/ Ag specific Rx |
| 02:45 PM - 03:35 PM | The Genomics menu for the practising rheumatologist Genetics Unzipped: Crafting the Perfect Genetics Test Order Decoding the Codes: The What, Why, and When of Whole Genome Sequencing |
Learning Objectives: Improving molecular Genetics test ordering: through a tailored approach 1. Understand the different types of genetic tests and their pros and cons 2. Depth of sequencing and why it matters 3. Understand the basics of variant interpretation Learning objectives 1. What are the situations where WGS is useful 2. Different applications of WGS 3. Unique considerations - reanalysis and revisiting data 4. WGS as a screening tool - what does evidence say ? |
| 03:35 PM - 04:15 PM | Sum up the day’s discussion: Building upon the concepts
learnt today. How all these nuts and bolts come together in
health, get disrupted in disease and how we apply this
understanding to diagnostics and therapeutics. ALL Delegates and Faculties TO PARTICIPATE |
|
| 04:15 PM | Vote of Thanks | |
