| CONVENER: Dr Sita Naik | ||||
| Time | Topic | Learning Objectives | Speakers | Chairperson |
| 09:00 | Opening Remarks: Dr Sita Naik | |||
| 09:00 - 09:40 | Nuts and Bolts of
Innate immune system Basic Overview of Innate Immune receptors Clinical Innate immune aberrations in AIRDs and applications in therapeutics |
Brief Overview of Innate Immunity:
focussing on TLRs How does it sense danger and react? Is it really a perfect creation? Innate immune aberrations in Immunodeficiency/ viral infections and AIRDs Applications in therapeutics - brief overview of TLR antagonists |
Dr Shailesh Dudhgaonkar (BBRC, Bengaluru) Prof Varun Dhir (Chandigarh) |
Prof. Dipankar Nandi (IISc, Bengaluru) Dr S Ganguly (Kolkata) Dr Pradeepta Sekhar Patro (Bhubaneswar) |
| 09:40 - 10:20 | Interferonopathies: Beyond the Viral Fad Basic Physiology of interferons and measuring their impact in disease Clinical Monogenic and polygenic interferonopathies and therapeutic options |
Introduction to IFN, its sensors,
signalling pathways, and
Interferon Stimulated genes.
Understanding the interferon
score. Mechanism of major heritable interferonopathies, overview of interferon aberrations in AIRDs (SLE, IIM) and its therapeutic potential |
Prof Amita Aggarwal (Lucknow) Dr Saumya Ranjan Tripathy (Cuttack) |
Dr Vara Prasad (Hyderabad) Dr Abhilasha Shah (Lalitpur, Nepal) Dr Aarti Sharma (Delhi) |
| 10:20 - 11:00 | Complimenting the complements Basic Biology of complements and its applied aspects Clinical Complements in Therapeutic development for AIRDs |
Regulation of complements as relevant to AIRDs
Relevant concepts learnt from pathogenesis of Hereditary angioneurotic edema, HUS and PNH
Development of therapeutics involving complements in autoimmune diseases focusing on Eculizumab and Avocapan (using C5a role in AAV). |
Dr Ankur Jindal (Chandigarh) Dr Ranjan Gupta (New Delhi) |
Dr Deepak Gupta (USA)
Dr Ashit Syngle (Chandigarh)) |
| Mobility Break 11:00 - 11:30 | ||||
| 11:30 - 12:00 | Inflammasome- the balancing act (far and beyond) | Inflammasome: Journey from physiologic role to disease states Therapeutic potential in Immune mediated and Non-immune diseases RCTs - targeting inflammasome components |
Dr Siddharth Jain (New Delhi) | Prof Annapurna Vyakarnam (Bengaluru) Dr Himanshu Pathak (Vadodara) |
| 12:00 - 12:30 | Immune memory-How to train your dragon ? | Innate and adaptive immune memory and its aberrations in AIRDs Mechanism of Vaccine memory Can it be harnessed for treatment of AIRDs? |
Dr Sudha Kumari (IISc, Bengaluru) | |
| 12:30 - 13:00 | Symphony of Cytokine Signalling: Practical Concepts | Overview of cytokine signalling pathways Learn how different cytokine signalling pathways crosstalk to fine-tune immune responses and maintain homeostasis and what happens when it gets dysregulated How is this knowledge applied in therapeutic strategies of autoimmune diseases? |
Dr Sakir Ahmed (Bhubaneshwar) | |
| Lunch 13:00 - 14:45 | ||||
| 13:45 - 14:15 | Targeting B cells from surface to Core | Brief overview of B cell biology Understanding the B cell targeted therapies Whether it is to be CD19/20 or 22, or BAFF/APRIL/ or combination/ sequential use? |
Dr Phani Kumar (Hyderabad) | Prof. Dipankar Nandi (IISc Bengaluru) Dr Sundeep Upadhyay (New Delhi) Prof Kamalanathan Sivasankaran (Vellore) |
| 14:15 - 14:45 | T cells biology and application in therapy of autoimmune diseases | Quick run through basics and brief review of Immuno-therapeutics including CAR T cells/ reg T cell/ Ag specific Rx | Dr Girdhari Lal (NCCS, Pune) | |
| 14:45 - 15:35 | The Genomics menu for the practising rheumatologist Genetics Unzipped: Crafting the Perfect Genetics Test Order Decoding the Codes: The What, Why, and When of Whole Genome Sequencing |
Improving molecular Genetics test ordering: through a tailored approach
|
Dr Gautham Arunachal Udupi (Clinical Geneticist, NIMHANS, Bengaluru) Dr Vinod Scaria (Genomics Scientist, Bengaluru) |
Prof Venkatesh Pai (Haridwar) Prof Sumita Danda (Vellore) |
| 15:35 - 16:15 | Sum up the day's discussion: Building upon the concepts
learnt today How all these nuts and bolts come together in health, get disrupted in disease and how we apply this understanding to diagnostics and therapeutics All Delegates and Faculties To Participate |
Lead discussant: Prof Sita Naik(New Delhi) Prof Amita Aggarwal (Lucknow) Prof Varun Dhir (Chandigarh) |
||
| 16:15 | Vote of Thanks | Dr Sandhya P, Dr Shivraj Padiyar | ||
